New Generation Antipsychotic Drugs and QTc Interval Prolongation

Ketamine-induced QTc interval prolongation

Sir, Ketamine is a noncompetitive antagonist of the N-methyl-D-aspartate (NMDA) receptor. It is widely used as a dissociative anesthetic and is also used as an adjunct in pain management, particularly in opioid-tolerant patients. It blocks calcium channels and depresses sodium channel function as well as having anticholinergic effects. It inhibits the re-uptake of the catecholamines and may hav...

DRUGS AND QTc INTERVAL DISPERSION

The measure of delayed ventricular repolarization most frequently used clinically is the ability of the new chemical entity to prolong the QTc interval on surface electrocardiogram. Intramyocardial dispersion of repolarization appears to play a more important role both in electrical stability of the ventricles and in arrhythmogenesis. The potential importance of myocardial dispersion of refract...

THE CLINICAL EVALUATION OF QT/QTc INTERVAL PROLONGATION AND PROARRHYTHMIC POTENTIAL FOR NON-ANTIARRHYTHMIC DRUGS

Antipsychotic drugs: prolonged QTc interval, torsade de pointes, and sudden death.

OBJECTIVE The authors review the mechanisms and establish the risk of torsade de pointes and sudden death with antipsychotic drugs. METHOD They present a review of original concepts, the distinction between familial and drug-induced cases of torsade de pointes, and the recognition of the role of noncardiac drugs in torsade de pointes and sudden death. They review the evidence linking QTc inte...

Impact of ABCB1 allelic variants on QTc interval prolongation.

PURPOSE Although the ABCB1 (P-glycoprotein) drug transporter is a constituent of several blood-tissue barriers (i.e., blood-brain and blood-nerve), its participation in a putative blood-heart barrier has been poorly explored. ABCB1 could decrease the intracardiac concentrations of drugs that cause QT prolongation and cardiotoxicity. EXPERIMENTAL DESIGN ABCB1-related romidepsin transport kinet...